Table 3.
FLS subpopulations according to their surface proteins and the corresponding top 5 TFs identified in samples of OA and RA FLS (microarray data).
| FLS subpopulations | CD34 | THY11 | CDH11 | Top 5 TF in OA FLS | Top 5 TF in RA FLS |
|---|---|---|---|---|---|
| A | − | − | + | SIX3, HOXA9, HOXC10, PPARG, SIX1 | STAT1, BATF, IRF4, NFKB2, LEF1 |
| B | − | − | − | SIX3, HOXA9, FOXC1, SIX1, EN1 | BATF, IRF4, STAT1, NFKB2, SP140 |
| C | − | + | − | Data not available | BATF, PRDM1, NFKB2, IRF4, FOXM1 |
| D | − | + | + | HOXC10, HOXA9, AR, SIX1, SIX3 | STAT1, BATF, LEF1, NFKB2, PML |
| E | + | − | + | HOXC10, ZBTB16, HOXA9, HLF, EMX2 | ZNF135, ZBTB16, HOXA9, HLF, HOXC10 |
| F | + | + | + | HLF, ZBTB16, EMX2, HOXA9, HOXC10 | EMX2, HLF, ZBTB16, ZNF44, AR |
| G | + | + | − | Data not available | BATF, GATA3, LEF1, TCF7, PRDM1 |
In bold are highlighted the 5 identified TFs and in italic the TFs that differ considerably in the respected subpopulation.