Table 5.
Results of ISMARA and DoRothEA analysis of the microarray and scRNA-seq datasets regarding the five master regulators identified by CoRegNet.
| Transcription factor | Synovial tissue microarray ISMARA Z-value/ranking | RA FLS microarray ISMARA Z-value/ ranking | Synovial tissue microarray DoRothEA ranking | RA FLS microarray DoRothEA ranking | RA FLS scRNA-seq DoRothEA ranking |
|---|---|---|---|---|---|
| POU2AF1 | Not identified | Not identified | Not identified | Not identified | Not identified |
| BATF | 6.90/1 | 1.72/ 57 | 10 | 235 | 22 |
| IRF4 | 2.76/96 | 2.69/11 | 11 | 6 | 12 |
| STAT1 | 1.30/264 | 0.41/426 | 3 | 10 | 9 |
| LEF1 | 3.05/74 | 1.18/134 | 115 | 213 | 75 |