A. LV systolic pressure at day 56 of pressure overload by 26-gauge transaortic constriction (TAC) in WT (left) and LZM (right). n=5 WT sham, 6 WT TAC Vehicle, 8 WT TAC sacubitril/valsartan; 3 LZM sham, 6 LZM TAC vehicle, 8 LZM TAC sacubitril/valsartan. B. Western blot for phosphorylated cardiac myosin binding protein C (cMyBP-C) on serine 273. Summary densitometry of p273 normalized to GAPDH is shown. n=7 WT TAC vehicle, 6 WT TAC sacubitril/valsartan; 6 LZM TAC vehicle, 7 LZM TAC sacubitril/valsartan. C. LV end diastolic diameter obtained by echocardiography at day 56 after pressure overload in WT (left) and LZM (right) mice. n=5 WT and 5 LZM sham; 8 WT TAC vehicle; 8 WT TAC sacubitril/valsartan; 11 LZM vehicle; 10 LZM TAC sacubitril/valsartan. *, p<0.05. Veh, vehicle; Sac/Val, sacubitril/valsartan. ADU, arbitrary densitometric units. EDD, end diastolic diameter.