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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: J Card Fail. 2020 May 25;26(9):769–775. doi: 10.1016/j.cardfail.2020.04.011

Figure 2. PKGIα leucine zipper domain mutation does not affect degree of TAC-induced pressure overload but induces LV dilation after chronic pressure overload.

Figure 2.

A. LV systolic pressure at day 56 of pressure overload by 26-gauge transaortic constriction (TAC) in WT (left) and LZM (right). n=5 WT sham, 6 WT TAC Vehicle, 8 WT TAC sacubitril/valsartan; 3 LZM sham, 6 LZM TAC vehicle, 8 LZM TAC sacubitril/valsartan. B. Western blot for phosphorylated cardiac myosin binding protein C (cMyBP-C) on serine 273. Summary densitometry of p273 normalized to GAPDH is shown. n=7 WT TAC vehicle, 6 WT TAC sacubitril/valsartan; 6 LZM TAC vehicle, 7 LZM TAC sacubitril/valsartan. C. LV end diastolic diameter obtained by echocardiography at day 56 after pressure overload in WT (left) and LZM (right) mice. n=5 WT and 5 LZM sham; 8 WT TAC vehicle; 8 WT TAC sacubitril/valsartan; 11 LZM vehicle; 10 LZM TAC sacubitril/valsartan. *, p<0.05. Veh, vehicle; Sac/Val, sacubitril/valsartan. ADU, arbitrary densitometric units. EDD, end diastolic diameter.