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. 2020 Oct 1;10:16293. doi: 10.1038/s41598-020-73207-9

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© The Author(s) 2020

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Changing the charge distribution of a protonated IDP using singly or multiply charged metal ions to replace one or several proton charges while maintaining the original 8+ ESI charge state. Singly charged ions (yellow) replace protons (blue), while each doubly charged ion (green) replaces two and each triply charged ion (red) three protons. Zwitterionic states are expected with deprotonated and additional protonated sites, and deprotonation and counterions (C²⁻, in grey) can account for the net charge of 8+.