Figure 7.

CCS profiles comparing conformational ensembles for the 8+ charge state of α syn without any (control) and with four Mg²⁺, Ca²⁺, Cu²⁺ or Zn²⁺ ions bound, either added as chloride or acetate salts in a 1:50 protein:metal ion ratio. All metal salts lead to compaction as also seen in Fig. 6, yet the compaction pattern is characteristic for every metal salt indicating that the counterions plays an important role, in spite of not being detected as bound to the protein. Intensity scale as in Fig. 1b.