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. 2020 Oct 1;10:16251. doi: 10.1038/s41598-020-73533-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A 44-year-old man with ROS1-rearranged lung adenocarcinoma with extensive lymph node metastases. (a) Transverse mediastinal CT image demonstrates a small solid nodule (arrow) in the right upper lobe, which is presumed to be a primary tumor. Left axillary lymph node enlargement (arrowhead) is also noted. (b) Transverse lung window CT image shows diffuse bronchial wall thickening (arrowheads), which represents lymphangitic carcinomatosis. (c) Fused PET/CT image demonstrates fluorodeoxyglucose (FDG)-avid right paratracheal (arrow) and left axillary (arrowheads) lymph nodes. (d) Maximum intensity projection image of PET shows intense FDG uptake in the primary tumor (thin arrow), cervical (open arrowheads), mediastinal (thick arrow), left axillary (arrowhead), and intraabdominal (open arrow) lymph node metastases.