Table 2.
CT features and disease spread patterns according to genetic mutation type.
| Features | ROS1 | EGFR | ALK | P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ROS1 vs EGFR | ROS1 vs ALK | |||||||||
| Primary tumor | ||||||||||
| Size (mm)* | 32 (14–100) | 35 (1–100) | 40 (15–100) | 0.196 | 0.370 | |||||
| Density | Solid | 20 (87) | 92 (77) | 24 (92) | 0.408 | 0.655 | ||||
| Subsolid | 3 (13) | 28 (23) | 2 (8) | |||||||
| Location | Central | 14 (61) | 75 (63) | 20 (77) | 0.883 | 0.224 | ||||
| Peripheral | 9 (39) | 45 (37) | 6 (23) | |||||||
| Border | Smooth | 4 (17) | 14 (12) | 2 (8) | ||||||
| Lobulated | 15 (65) | 56 (47) | 15 (58) | 0.111 | 0.347 | |||||
| Spiculated | 4 (17) | 50 (42) | 9 (34) | |||||||
| Air-bronchogram | 3 (13) | 49 (41) | 6 (23) | 0.011 | 0.472 | |||||
| Pleural retraction | 11 (48) | 83 (69) | 13 (50) | 0.048 | 0.879 | |||||
| Central low-attenuation | 7 (30) | 38 (32) | 10 (38) | 0.907 | 0.556 | |||||
| Calcification | 1 (4) | 20 (17) | 5 (19) | 0.198 | 0.194 | |||||
| Lymph node metastases | 21 (91) | 96 (80) | 21 (81) | |||||||
| N0 | 2 (9) | 24 (20) | 5 (19) | |||||||
| N1 | 1 (4) | 5 (4) | 1 (4) | 0.047 | 0.803 | |||||
| N2 | 4 (17) | 22 (18) | 3 (12) | |||||||
| N3 | 16 (70) | 69 (58) | 17 (65) | |||||||
| Distant metastases | ||||||||||
| Lung metastasis | Miliary | 0 | 10 (8) | 0 | ||||||
| Scattered | 5 (22) | 36 (30) | 9 (35) | 0.145 | 0.895 | |||||
| Lymphangitic | 5 (22) | 14 (12) | 4 (15) | |||||||
| Aerogeneous | 1 (4) | 1 (1) | 1 (4) | |||||||
| Pleural | 14 (61) | 55 (46) | 16 (62) | 0.186 | 0.962 | |||||
| Pericardial | 7 (30) | 2 (2) | 2 (8) | < 0.001 | 0.060 | |||||
| Pleural effusion | 12 (52) | 34 (28) | 10 (29) | 0.025 | 0.336 | |||||
| Extrathoracic | Liver | 4 (17) | 18 (15) | 6 (23) | 0.756 | 0.730 | ||||
| Adrenal | 3 (13) | 15 (13) | 5 (19) | 1.000 | 0.707 | |||||
| Brain | 3 (13) | 47 (39) | 7 (27) | 0.017 | 0.299 | |||||
| Lymph nodes | 4 (17) | 4 (3) | 5 (19) | 0.023 | 1.000 | |||||
| Bone | 7 (30) | 50 (42) | 13 (50) | 0.360 | 0.245 | |||||
Unless otherwise indicated, data are presented as number of patients with the percentage in parentheses.
*Data are presented as the median with the range in parentheses.