Table 3.

Cancellous vertebral histomorphometry of 4 month old BGLAP-Cre;Nfatc1^Δ/Δ;Nfatc2^Δ/Δ male mice and littermate controls.

	Control n = 4	Nfatc1Δ/Δ;2Δ/Δ N = 9
Bone Volume/Total Volume (%)	22.1 ± 5.4	16.4 ± 4.0+
Trabecular Number (1/mm)	4.5 ± 0.7	3.9 ± 0.8
Trabecular Thickness (μm)	49 ± 6	43 ± 7
Osteoblasts/Bone Perimeter (1/mm)	6.1 ± 0.9	3.4 ± 1.4*
Osteoblast Surface/Bone Surface (%)	7.7 ± 1.6	4.3 ± 2.0*
Osteoid Surface/Bone Surface (%)	0.8 ± 0.3	0.1 ± 0.1*
Osteoclasts/Bone Perimeter (1/mm)	1.6 ± 0.4	2.1 ± 0.8
Eroded Surface/Bone Surface (%)	1.8 ± 0.7	2.1 ± 1.0
Mineral Apposition Rate (μm/day)	0.8 ± 0.2	0.8 ± 0.1
Mineralizing Surface/Bone Surface (%)	2.6 ± 0.7	1.7 ± 1.0
Bone Formation Rate (μm3/μm2/day)	0.022 ± 0.01	0.014 ± 0.01

Bone histomorphometry was performed in L3 vertebral bodies from 4 month old male BGLAP-Cre;Nfatc1^Δ/Δ;Nfatc2^Δ/Δ mice and sex-matched Nfatc1^loxP/loxP;Nfatc2^loxP/loxP littermates (control). Values are means ± SD.

^*Significantly different between BGLAP-Cre;Nfatc1^Δ/Δ;Nfatc2^Δ/Δ and control, p < 0.05;

⁺p 0.0547.