Skip to main content
. Author manuscript; available in PMC: 2021 Jan 13.
Published in final edited form as: Nat Microbiol. 2020 Jul 13;5(10):1217–1231. doi: 10.1038/s41564-020-0750-9

Extended Data Fig. 10. Non-degradative ubiquitination of RNA-binding proteins promotes efficient adenoviral RNA processing.

Extended Data Fig. 10

During wild-type (WT) Ad5 infection the E1B55K/E4orf6 complex induces ubiquitination of RNA-binding proteins RALY and hnRNP-C to facilitate efficient viral late RNA processing. Ubiquitination regulates interaction of these host proteins with viral RNA to facilitate viral infection. In the absence of the E1B55K/E4orf6 complex ubiquitin ligase activity, the RBPs bind more to viral late mRNAs and limit RNA processing and protein production. RNP=ribonucleoprotein.