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. Author manuscript; available in PMC: 2021 Jan 13.
Published in final edited form as: Nat Microbiol. 2020 Jul 13;5(10):1217–1231. doi: 10.1038/s41564-020-0750-9

Extended Data Fig. 3. Di-glycine remnant profiling and whole cell proteome data for RNA-binding proteins enriched within predicted E1B55K/E4orf6 substrates.

Extended Data Fig. 3

a-b, Gene ontology analysis identified RNA-binding proteins enriched in proteins that exhibited an increase in normalized protein-based ubiquitin abundance of log2 fold change >1 following 10 h expression of E1B55K/E4orf6. a, Enriched RNA-binding proteins ubiquitination log2 fold changes (left) and whole cell protein abundance log2 fold changes (right) comparing 0 and 10 h of E1B55K/E4orf6 expression. b, Heat map showing relative ubiquitination of indicated lysine residues at 0, 6, 8, and 10 h of E1B55K/E4orf6 expression within enriched RNA-binding proteins. Colors correspond to the average z-score of the ubiquitination. All data are representative of three biologically independent experiments.