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Exosomes from the plasma of HNSCC patients promote a M2-like phenotype in primary macrophages. Macrophages were treated with exosomes from the plasma of normal donors (ND), patients with active disease (HNSCC) or with the equivalent volume of PBS (Mϕ). After 72 h of incubation the marker expression profile of M1 markers CD86 (A) and EGFR (B) and M2 markers CD206 (C) and Arginase-1 (D) was analyzed by flow cytometry. Values represent means ± SD. **p < 0.01 vs. Mϕ; **p < 0.001 vs. Mϕ.
