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. Author manuscript; available in PMC: 2021 Oct 15.
Published in final edited form as: Biol Psychiatry. 2020 May 11;88(8):611–624. doi: 10.1016/j.biopsych.2020.04.025

Figure 2. miR-218 levels in the PFC determine susceptibility versus resilience to chronic stress in adulthood.

Figure 2.

(A) Experimentally-induced increased miR-218 expression in adult PFC pyramidal neurons prevents stress-induced DCC upregulation, maintaining dendritic structure and optimal synaptic connectivity. (B) Stress-induced miR-218 downregulation in adult PFC pyramidal neurons results in DCC upregulation, causing dendritic structure modifications and aberrant synaptic connectivity.