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. Author manuscript; available in PMC: 2021 Oct 15.
Published in final edited form as: Biol Psychiatry. 2020 May 11;88(8):611–624. doi: 10.1016/j.biopsych.2020.04.025

Figure 3. Stress in adolescence may alter ongoing PFC development by disrupting DCC expression in dopamine axons.

Figure 3.

(A) Sagittal representation of the adult mesocorticolimbic system where DA axons expressing DCC receptors (in purple) innervate the NAcc, whereas DA axons that lack DCC receptors (in green) innervate the PFC. (B) Stress in adolescence may alter the topographic organization of mesolimbic and mesocortical DA axons in adulthood. For example, stress may reduce DCC expression in DA axons that normally recognize the NAcc as their final target, inducing their ectopic growth to the PFC.