Fig. 2.

Schematic of the organ-level model. (a) of SC tissue, including vascular space, endothelial space (with endosomal sub-compartments), interstitial space and cells space. The SC dose was administrated into the interstitial space, from where mAbs can be drained into local lymphatic capillaries to enter the lymphatic system or be absorbed via blood perfusion. (b) of endosomal sub-compartments, representing the interaction of FcRn and IgG at a certain pH value (x). (c) of the lymphatic vessel, which is divided into lymph flow and lymphatic endothelial space