Fig. 6.

Correlation of observed SC PK characteristics versus estimated SC tissue model parameters. (a) Negative association between observed bioavailability (%) and estimated $C{L}_{\mathit{\text{LymCap}}}^{SC}$ (p = 6.77×10⁻⁰⁵). (b) No significant association between observed bioavailability (%) and estimated $S_{\mathit{\text{LymUpt}}}^{SC}$ (p = 0.547). (c) No significant association between observed T_max (day) and estimated $C{L}_{\mathit{\text{LymCap}}}^{SC}$ (p = 0.217). (d) Negative correlation between observed T_max (day) and estimated $S_{\mathit{\text{LymUpt}}}^{SC}$ (p = 0.000143).