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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2020 Jun 4;47(5):385–409. doi: 10.1007/s10928-020-09691-3

Table 5.

Fixed parameter values for central venous and lymphatic systems

Parameter (unit) Value Description Ref.
Central venous
QPlasma (ml/day) 3.152×106 Plasma flow (see text)
VPlasma (ml) 1202 Central plasma volume (see text)
IgG0 (nmol/day) 1.540×104 Production rate of endogenous IgG [41]
Central lymphatic
VLymNode (ml) 175.2 Volume of lymph node compartment [35, 36]
QLymNode (ml/day) 4000 Post-nodal lymph flow [35]
kLymNode (day−1) 23.83 Rate constant of mAb leaving lymph node (see text)
VLymVes (ml) 11.35 Volume of lymphatic vessel compartment [20, 37]
QLymVes (ml/day) 4000 Lymph flow rate from lymphatic vessel compartment (see text)
σ 0.2 Lymph reflection coefficient [14, 15]