Table 6.

Fixed parameter values for endosomal processing and trans-capillary transport of mAbs

Parameter (unit)	Value	Description	Ref.
All organs, tissues and mAbs
τ (day)	0.001875	Transit time of IgG between endosomal sub-compartments	[15]
fIgGrecyc	0.7150	IgG recycling fraction of IgG-FcRn complex back to vascular space	[13]
$k_{on}^{6.0}$ (nM−1day−1)	13.42	Association rate constant between IgG and FcRn at pH = 6.0	[15]
$k_{on}^{6.5}$ (nM−1day−1)	1.354	Association rate constant between IgG and FcRn at pH = 6.5	[15]
$k_{on}^{7.0}$ (nM−1day−1)	0.6336	Association rate constant between IgG and FcRn at pH = 7.0	[15]
$k_{on}^{7.4}$ (nM−1day−1)	0	Association rate constant between IgG and FcRn at pH = 7.4	[15]
$k_{off}^{6.0}$ (day−1)	573.1	Dissociation rate constant between IgG and FcRn at pH = 6.0	[15]
$k_{off}^{6.5}$ (day−1)	573.1	Dissociation rate constant between IgG and FcRn at pH = 6.5	[15]
$k_{off}^{7.0}$ (day−1)	573.1	Dissociation rate constant between IgG and FcRn at pH = 7.0	[15]
$k_{off}^{7.4}$ (day−1)	0	Dissociation rate constant between IgG and FcRn at pH = 7.4	[15]
rS (nm)	4.440	Small pore radius	[21]
rL (nm)	22.85	Large pore radius	[21]
αS	0.9580	Fractional hydraulic conductance of small pores	[21]
αL	0.04200	Fractional hydraulic conductance of large pores	[21]
Adjusted for mAb MW (150 kDa IgG as an example); All organs and tissues
ae (nm)	4.810	Stokes Einstein radius	[21]
σS	0.9980	Small pore vascular reflection coefficient	[21]
σL	0.1800	Large pore vascular reflection coefficient	[21]
A/A0S	9.28×10−7	Fractional accessible pore size of small pore	[21]
A/A0l	0.3490	Fractional accessible pore size of large pore	[21]
PeS	9.820	Peclet number of small pores	[21]
PeL	4.480	Peclet number of large pores	[21]
Adjusted for mAb MW and individual organs and tissues (150 kDa IgG in liver as an example)
$P{S}_S^{\mathit{\text{Liver}}}$ (ml/day)	0.1560	Permeability-surface area product of small pores	[21]
$P{S}_L^{\mathit{\text{Liver}}}$ (ml/day)	97.61	Permeability-surface area product of large pores	[21]
$J_{iso}^{\mathit{\text{Liver}}}$ (ml/day)	481.5	Circular isogravimetric flow	[21]
$J_S^{\mathit{\text{Liver}}}$ (ml/day)	732.3	Lymph flow through small pores	[21]
$J_L^{\mathit{\text{Liver}}}$ (ml/day)	534.7	Lymph flow through large pores	[21]