Fig. 3.

MPL/TDCM-induced anti-tumor IgM responses are independent of FcγR, but dependent on TLR4. a–c WT and FcγR^−/− (a, c) and TLR4^−/− (b, c) mice were treated with MPL/TDCM i.p., with IgM binding (MFI) to TA3-Ha cells examined for serum harvested on d0, 5, and 9 using flow cytometry. Values in c indicate relative changes in IgM MFI values at d9 versus those obtained for d0. Values represent means ± SEM. Asterisks (*) indicate significant differences from WT mice (p < 0.05, n = 5–7 mice/group)