Table 4.

Effect of JZL184 on 2-AG and free AA levels in the brain. JZL184 selectively increases 2AG levels with an associated decrease in AA levels in various brain regions. Data are expressed as mean ± S.E.M. of 6–7 mice/group.

2-AG Levels (nmol/g)	PFC	STR	HIPP	THAL
Vehicle	7.51 ± 1.66	9.75 ± 1.75	11.53 ± 2.11	9.72 ± 2.85
Nicotine (0.5 mg/kg)	6.31 ± 1.82	10.57 ± 2.94	10.08 ± 1.91	9.04 ± 1.01
JZL (24 mg/kg)	196.72 ± 29.38*	144.51 ± 9.88*	140.66 ± 6.81*	72.44 ± 5.26*
JZL + Nicotine	212.76 ± 11.19*	152.20 ± 24.07*	165.31 ± 7.60*	73.53 ± 1.23*
AA Levels (nmol/g)	PFC	STR	HIPP	THAL
Vehicle	218.05 ± 16.46	149.85 ± 7.94	187.70 ± 7.59	89.40 ± 3.83
Nicotine (0.5 mg/kg)	224.92 ± 30.34	147.09 ± 25.93	172.22 ± 17.86	84.83 ± 9.46
JZL (24 mg/kg)	135.50 ± 20.20*	83.18 ± 29.38*	117.89 ± 10.20*	48.07 ± 2.59*
JZL + Nicotine	121.42 ± 19.88*	76.32 ± 13.58*	100.88 ± 8.53*	40.64 ± 0.67*

^*p<0.05 vs vehicle.