Table 1.
FUS parameters.
| Condition | PA (MPa) | tA (ms) | PU (MPa) | tU (ms) | tOFF (ms) | PRF (Hz) | NOC |
|---|---|---|---|---|---|---|---|
| standard1-FUS | 1.25 | - | - | - | - | 1 | 25,000 |
| standard2-FUS | 2.5 | – | – | – | – | 1 | 25,000 |
| standard3-FUS | 0.75* | – | – | – | – | 1 | 25,000 |
| standard4-FUS | 1.5* | – | – | – | – | 1 | 25,000 |
| AU1-FUS (in vitro) | 0.3 | 500 | 0.5 | 90 | 300 | 30 | 10,000 |
| AU2-FUS (in vitro) | 0.38 | 500 | 0.63 | 90 | 300 | 50 | 10,000 |
| AU3-FUS (in vitro) | 0.25 | 1000 | 0.63 | 90 | 300 | 100 | 1000 |
| AU-FUSin-vivo | 0.075* | 1000 | 0.188* | 90 | 300 | 100 | 1000 |
PA, PU—peak-negative pressure in megapascal (MPa) for aggregation and uncaging sequences, respectively (*accounting for ~70% skull attenuation; see “Methods” and Supplementary Figs. 4 and 5), tA—pulse duration in milliseconds (ms) of aggregation sequence, tU—duration in milliseconds (ms) of uncaging sequence, tOFF—duration in milliseconds (ms) of delay between the end of the uncaging sequence and the start of the following aggregation sequence, PRF—pulse-repetition frequency in Hz, NOC—number of cycles.