Skip to main content
. Author manuscript; available in PMC: 2021 Jan 27.
Published in final edited form as: Nat Ecol Evol. 2020 Jul 27;4(10):1332–1341. doi: 10.1038/s41559-020-1261-z

Extended Data Fig. 5. Reintroduced alleles have different predicted fitness effects than Neanderthal-derived alleles.

Extended Data Fig. 5

(a) In modern European (EUR) populations, RAs are predicted to be significantly less deleterious than NDAs by CADD (median scaled CADD: NDA=2.67; RA=2.1; P ≈ 0). The upper tail of highly deleterious mutations (CADD score >10) is highlighted in the inset. Results are similar for unscaled scores. (b) At the haplotype level, the maximum RA CADD score per introgressed haplotype is significantly lower than for NDAs (median scaled max CADD: NDA=13.3; RA=5.8; P ≈ 0). This is in part due to the overall difference demonstrated in (a) and to the greater number of NDAs per haplotype. RAs are rarely the most deleterious variant per haplotype. Results in East Asian and South Asian populations are similar (data not shown).