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. Author manuscript; available in PMC: 2021 Jan 27.
Published in final edited form as: Nat Ecol Evol. 2020 Jul 27;4(10):1332–1341. doi: 10.1038/s41559-020-1261-z

Extended Data Fig. 6. PolyPhen2 predicts RAs to be less damaging than NDAs.

Extended Data Fig. 6

PolyPhen2 is more likely to classify RAs as “benign” in all three Eurasian populations. Conversely, NDAs are significantly more likely to be classified as “damaging” in both EUR and SAS populations. The y-axis reports the difference in PolyPhen category membership for each population (i.e., the fraction all RAs in the population in the PolyPhen category minus the fraction of all NDAs in population in the PolyPhen category). Per population hypergeometric test is calculated on the enrichment (positive delta) or depletion (negative delta) for RA content within each PolyPhen category.