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. 2020 Oct 1;10:16192. doi: 10.1038/s41598-020-73055-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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On-chip evaluation of wound closure and cell migration of wounded fibroblast monolayers maintained under standard culture conditions and complete culture medium. (A) Time-lapse images of the wound defect at 0, 4, 8, 12, 16 and 20 h post-wounding. The wound edges where the membrane interfaced the microchannel surface are highlighted with dashed lines. (Scale bar = 200 µm). (B) Analysis of average wound area as a function of cultivation time. (n = 4). (C,D) Average cell migration rate of four hour intervals for three individual time windows including 0–4 h, 8–12 h and 16–20 h post-wounding (C), and wound closure at three selected time-points including 4, 12 and 20 h post-wounding (D). Data is expressed as mean ± SD. Data sets were tested with unpaired student’s t-test with 99% confidence level, ns non-significant, **p < 0.01, ***p < 0.001, ****p < 0.0001.