Table 2.
Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value of the Infant-Toddler Checklist for distinguishing any delays (ASD + Non-TD) from TD in a high-risk sample.
| ASD + Non-TD outcome at 36 months |
TD outcome at 36 months |
|||||||
|---|---|---|---|---|---|---|---|---|
| NON-TD (True Positives) |
TD (False Negatives) |
NON-TD (False Positives) |
TD (True Negatives) |
Sensitivity1 (95% CI) |
Specificity1 (95% CI) |
PPV1 (95% CI) |
NPV1 (95% CI) |
|
| 6 months | 38 | 21 | 73 | 56 | 62% (50% - 74%) | 42% (33% - 50%) | 31% (23% - 39%) | 72% (63% - 82%) |
| 9 months | 37 | 34 | 70 | 106 | 52% (41% - 63%) | 60% (53% - 67%) | 35% (27% - 44%) | 75% (68% - 82%) |
| 12 months | 47 | 29 | 70 | 109 | 62% (51% - 73%) | 61% (54% - 68%) | 40% (31% - 49%) | 79% (73% - 86%) |
| 18 months | 35 | 37 | 36 | 141 | 51% (40% - 62%) | 77% (71% - 84%) | 49% (38% - 60%) | 79% (73% - 85%) |
| 24 months | 38 | 32 | 23 | 150 | 57% (46% - 68%) | 85% (80% - 91%) | 62% (51% - 74%) | 83% (77% - 88%) |
1
Since sample size varied by visit, multiple imputations for incomplete longitudinal binary data were conducted. Estimates and CI were calculated after generating 100 data sets using multiple imputations and pooling the results.