Table 3.
Comparison of Rectoanal Pressures in the Left Lateral and Seated Positions
| Healthy controls (n=64) | Constipation (n=136) | |||||||
|---|---|---|---|---|---|---|---|---|
| Rectoanal parameters† | Left lateral position | Seated position | P-value‡ | Left lateral position | Seated position |
P-value‡ | P-value left lateral -Controls vs constipation | P-value Seated -Controls vs constipation |
| Anal pressure - rest, Manoview™ | 85 (24) | 97 (27) | .0003 | 90 (28) | 105 (34) | <.0001 | .20 | .07 |
| Anal pressure - squeeze, Manoview™ | 203 (58) | 192 (52) | .01 | 183 (67) | 159 (68) | <.0001 | .02 | .0001 |
| Anal pressure - Valsalva, Manoview™ | 127 (43) | 128 (41) | .74 | 125 (44) | 133 (48) | .004 | .72 | .47 |
| Rectal pressure - rest, Manoview™ | 4 (7) | 32 (20) | <.0001 | 6 (8) | 28 (16) | <.0001 | .16 | .15 |
| Rectal pressure - rest, new analysis | 7 (6) | 33 (20) | <.0001 | 8 (11) | 30 (17) | <.0001 | .25 | .34 |
| Rectal pressure – evacuation, Manoview™ | 33 (20) | 66 (40) | <.0001 | 33 (28) | 62 (36) | <.0001 | .94 | .39 |
| Rectal pressure – evacuation, new analysis | 33 (18) | 63 (34) | <.0001 | 32 (26) | 58 (29) | <.0001 | .91 | .30 |
| Rectal pressure increment – evacuation, Manoview™ | 29 (19) | 34 (30) | .03 | 27 (26) | 33 (28) | .02 | .46 | .58 |
| Rectal pressure increment – evacuation, new analysis | 26 (17) | 30 (21) | .05 | 24 (22) | 28 (21) | .02 | .58 | .43 |
| Anal pressure – evacuation, Manoview™ | 73 (22) | 83 (25) | .0006 | 83 (27) | 97 (34) | <.0001 | .002 | .001 |
| Anal pressure - evacuation, new analysis | 65 (22) | 67 (21) | .44 | 74 (28) | 81 (31) | .005 | .007 | .0002 |
| Change in anal pressures– evacuation, Manoview™ | −12 (31) | −13 (32) | .66 | −4 (26) | −4 (29) | .60 | .07 | .04 |
| Change in anal pressures - evacuation, new analysis | −2 (17) | −12 (19) | .0002 | 6 (18) | 2 (20) | .02 | .001 | <.0001 |
| Rectoanal gradient- evacuation, Manoview™ | −39 (25) | −17 (42) | <.0001 | −51 (33) | −35 (46) | <.0001 | .006 | .004 |
| Rectoanal gradient- evacuation, new analysis | −32 (28) | −4 (39) | <.0001 | −42 (32) | −23 (41) | <.0001 | .03 | .001 |
| Rectal threshold - first sensation, ml | 45 (14) | 46 (17) | .71 | 49 (20) | 54 (23) | .02 | .21 | .05 |
| Rectal threshold - desire to defecate, ml | 70 (17) | 67 (20) | .51 | 84 (32) | 87 (34) | .45 | .002 | .0001 |
| Rectal threshold - urge to defecate, ml | 117 (29) | 123 (46) | .42 | 123 (45) | 125 (46) | .83 | .39 | .90 |
†
Values are in mmHg unless stated otherwise
‡
Left lateral vs seated position