Table 3.
Univariate and multivariate for progression and death
| Univariate | Multivariable | |||||||
|---|---|---|---|---|---|---|---|---|
| Outcome | Risk factor | Level | N | Events | HR (95% CI) | p-value | (95% CI) | p-value |
| Progression to any PCD | Glycosylation | No glycosylation | 389 | 38 | Reference | Reference | ||
| Glycosylation | 25 | 12 | 6.4 (3.3, 12.4) | <0.001 | 7.8 (4.0, 15.3) | <0.001 | ||
| Mayo Risk Group11 | 0 factors | 161 | 11 | Reference | Reference | |||
| Any 1 factor | 144 | 13 | 1.4 (0.6, 3.2) | 0.398 | 1.2 (0.5, 2.7) | 0.648 | ||
| Any 2 factors | 63 | 13 | 3.7 (1.6, 8.2) | 0.002 | 3.2 (1.4, 7.2) | 0.005 | ||
| Any 3 factors | 16 | 10 | 13.3 (5.0, 31.4) | <0.001 | 13.4 (5.6, 32.0) | <0.001 | ||
| Progression or death | Glycosylation | No glycosylation | 389 | 307 | Reference | Reference | ||
| Glycosylation | 25 | 22 | 1.6 (1.1, 2.5) | 0.027 | 1.6 (0.99, 2.5) | 0.051 | ||
| Mayo Risk Group11 | 0 factors | 161 | 118 | Reference | Reference | |||
| Any 1 factor | 144 | 117 | 1.2 (0.9, 1.5) | 0.224 | 1.2 (0.9, 1.5) | 0.267 | ||
| Any 2 factors | 63 | 56 | 1.4 (1.03, 2.0) | 0.033 | 1.4 (1.02, 1.9) | 0.041 | ||
| Any 3 factors | 16 | 15 | 1.7 (0.98, 2.9) | 0.060 | 1.7 (0.98, 2.9) | 0.060 | ||
Mayo risk factors for progression from MGUS to myeloma and related conditions:11 free light chain ratio abnormal, M-spike ≥ 1.5, heavy chain isotype not IgG