Table 1:
Prevalence of Exudative Retinal Detachment in the Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study.
| Characteristic (at time of presentation) | Value | ERD Cases (%) | *Adjusted OR of ERD (95% CI) |
|---|---|---|---|
| Age | ≥ 35 | 108 (61.36) | 1.00 |
| < 35 | 68 (38.64) | 1.06 (0.72 – 1.58) | |
| Gender | Male | 78 (44.32) | 1.00 |
| Female | 98 (55.68) | 0.72 (0.50 – 1.04) | |
| Race | White | 81 (46.02) | 1.00 |
| African American | 50 (28.41) | 2.83 (1.80 – 4.44) | |
| Hispanic | 32 (18.18) | 4.90 (2.88 – 8.33) | |
| Type of inflammation, compared with anterior uveitis*,1 | VKH | 69 (39.20) | 109.4 (55.67 – 218.3) |
| Retinochoroiditis | 4 (2.27) | 9.18 (1.52 – 29.65) | |
| Sympathetic ophthalmia | 2 (1.14) | 8.43 (0.60 – 32.64) | |
| Primary or secondary panuveitis | 26 (14.77) | 7.09 (3.16 – 14.65) | |
| Multifocal choroid panuveitis | 5 (2.84) | 4.51 (1.36 – 16.52) | |
| Other posterior uveitis | 15 (8.52) | 16.91 (5.63 – 35.73) | |
| Posterior scleritis | 7 (3.98) | 41.63 (10.04 – 104.7) | |
| Necrotizing scleritis | 3 (1.70) | 8.11 (0.96 – 27.35) | |
| AC cells | No cell | 91 (51.70) | 1.00 |
| 0.5+ | 30 (17.05) | 1.54 (0.98 – 2.41) | |
| 1.0+ | 14 (7.95) | 1.07 (0.57 – 2.01) | |
| 2.0+ | 25 (14.20) | 2.31 (1.33 – 4.02) | |
| 3.0+ and greater | 16 (9.09) | 2.64 (1.30 – 5.38) | |
| Vitreous cells* | No cell | 77 (46.39) | 1.00 |
| 1.0+ | 36 (21.69) | 1.65 (0.99 – 2.77) | |
| 2.0+ | 25 (15.06) | 1.43 (0.80 – 2.55) | |
| 3.0+ and greater | 12 (7.23) | 2.04 (0.89 – 4.69) | |
| Vitreous haze* | None | 117 (74.05) | 1.00 |
| 1.0+ | 29 (18.35) | 1.57 (0.95 – 2.60) | |
| 2.0+ | 8 (5.06) | 1.14 (0.48 – 2.71) | |
| 3.0+ | 4 (2.53) | 1.18 (0.34 – 4.12) | |
| Inflammation activity | Inactive | 18 (10.34) | 1.00 |
| Slightly active | 22 (12.64) | 2.93 (1.40 – 6.15) | |
| Active | 134 (77.01) | 5.06 (2.85 – 9.00) | |
| Band keratopathy | No | 164 (93.18) | 1.00 |
| Yes | 12 (6.82) | 3.14 (1.59 – 6.22) |
Adjusted analysis adjusts for: type of inflammation, bilateral inflammation, smoking status, age category, and gender. 95% CI produced using Profile. Exudative retinal detachment (ERD); Odds ratio (OR), Confidence interval (CI), Vogt-Koyanagi-Harada (VKH); Profile log likelihood ratio confidence interval computed using only one eye per patient. “Other posterior uveitis” includes acute posterior multifocal placoid pigment epitheliopathy (APMPEE), multiple evanescent white dot syndrome (MEWDS), serpiginous choroiditis, and neuroretinitis. Other forms of uveitis and scleritis not associated with significantly higher risk than anterior uveitis are not listed as potential risk factors for but were included in the analysis.
The rest of the cases were kinds of inflammation unassociated with ERD. These are: anterior uveitis 21 (11.93%), intermediate uveitis 11 (6.25%), retinal vasculitis 4 (2.27%), anterior scleritis 8 (4.55%), and other 1 (0.57%).