Fig. 1:

Schematic of Xie2-64 structure, receptor binding profiles, and computational modeling of Xie2-64 or SR144528 binding in the crystal structure of CB₂R. A, Molecular structure of Xie2-64 and alignment of Xie2-64 or SR144528 in the CB₂R crystal structure. Xie2-64 is a novel CB₂R inverse agonist recently synthesized (Yang et al., 2013; compound #57). B, Detailed interactions between SR144528 and CB₂R. C, Detailed interactions between Xie2-64 and CB₂R.