Figure 1.
Study paradigm detailing the longitundial design and pre-treatment study visit day and individual trajectores of children’s BIM z-scores throughout study. Study participants underwent a pre-treatment study visit, attended a family-based behavioral treatment (FBT) weight loss intervention for 6 months, then returned for 3 follow-up study vists (A). Study procedures for the pre-treatment visit included a 1-week lead-in period during which participants wore activity monitors and completed 3 food records (B). Participants arrived fasted, had a blood draw, were provided a standardized breakfast meal representing 10% of their estimated daily caloric need, underwent bioelectrical impedance analysis (BIA) to assess body composition, completed questionnaires, and underwent the first fMRI 3 hours (180 minutes) after the breakfast meal. Following the first fMRI, participants were provided a standarized test meal of macaroni and cheese represeting 33% of their estimated daily caloric need and underwent a 2nd fMRI 30 minutes later which was followed by an ad libitum buffet meal. Serial appetite ratings were completed approximately every 30 minutes throughtout the pre-treatment visit (represented by triangles). Individual BMI z-scores from pre-treatment to 1 year after completion of a 6-month FBT intervention (C). Pre-T, pre-treatment; Post-T, post-treatment.