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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Hum Pathol. 2020 Jul 12;103:72–82. doi: 10.1016/j.humpath.2020.07.010

Table 2.

Summary of marker expression in 560 paragangliomas and epithelial neuroendocrine tumors.

Tumor category n = Keratins AE1/AE3 GATA3 Tyrosine Hydroxylase positive cells CDX2 TTF1 SOX10** 0/1/2/3 GFAP** 0/1/2/3
Pheochromocytoma, adrenal 142 8/142* 132/142 (93) 138/142 (97) 0/145 2/142* 30/33/35/26 109/4/1/1
Paraganglioma, retroperitoneal 49 3/49* 46/49 (94) 43/49 (88) 0/48 0/48 4/11/18/12 44/1/0/0
Paraganglioma, urinary bladder 8 0/8 6/8 (75) 8/8 (100) 0/6 0/6 0/2/1/3 All negative
Paraganglioma, neck 54 1/54* 51/54 (93) 20/54 (37) 0/54 0/54 3/2/19/30 14/12/14/14
Paraganglioma, thoracic 9 0/9 9/9 (100) 9/9 (100) 0/9 0/9 1/0/0/7 3/2/1/2
Gangliocytic paraganglioma 9 9/9 0/9 (0) 2/9* (22) 0/9 0/9 9/9 ** All negative
Cauda equina paraganglioma 3 3/3 0/3 (0) 2/3* (0) 0/2 0/2 0/2/0/0 All negative
Carcinoid/NET, GI-tract, Gr.1–2 81 81/81 0/81 (0) 6/81* (7) 73/81 0/81 79/2/0/0 81/0/0/0
Carcinoid/NET, Lung and thymus, Gr. 1–2 42 42/42 1/42* (2) 11/42* (26) 0/41 19/41 28/7/4/2 All negative
NET, pancreas, Gr. 1–2 78 76/78 5/77* (6) 7/77* (9) 22/78 1/78 74/4/1/0 All negative
Medullary carcinoma, thyroid 37 37/37 0/37 (0) 1/37* (2) 0/37 37/37 37/0/0/0 All negative
Neuroendocrine tumor, Gr. 3, Various organs 16 15/16 0/16 (0) 2/16* (13) 8/16 7/16 16/0/0/0 All negative
Small cell carcinoma, lung 32 30/32 0/31 (0) 0/32 (0) 0/30 30/32 30/0/0/0 ND
Total 560
*

Positivity was usually focal.

**

Expression only in sustentacular cells/spindled Schwannian cells. Number of cases with each score value (Number of positive cells per 0.2 mm2 Scored 0–3: 0 = negative, 1 = ≤10, 2 = 11–49, 3= ≥50). Numbers for SOX10 and GFAP represent the cases with no positivity (Score 0) to >50 cells positive (Score 3).

Details of scoring for SOX10 and GFAP are shown in materials and methods.