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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Angiogenesis. 2020 Aug 11;23(4):685–698. doi: 10.1007/s10456-020-09740-y

Fig. 9. Diagram of signaling pathway of IQGAP1 in regulation of VEGFR2-Src-Rac1 activation in choroidal angiogenesis.

Fig. 9.

In choroidal endothelial cell, upon binding to VEGF, VEGFR2 interacts with IQGAP1, leading to VEGFR2 activation. Activated VEGFR2 recruits Src and results in Src phosphorylation. Once Src is activated by VEGFR2 and IQGAP1, it activates Rac1 potentially involving phosphorylation of vav guaninenucleotide exchange factor 2 (Vav2), then leads to Src activation (from Rac1GDP to Rac1GTP). Once Rac1 is activated, Rac1GTP binds to IQGAP1 via GRD domain. This interaction between IQGAP1 and Rac1 maintains persistent Rac1 activation, which leads to CEC migration and CNV formation (the diagram was produced with BioRender).