Table 1.

Associations of BMI with regional brain volume

Brain region	Model	r	β	p value
IFG	1	−0.247	−0.227	0.001*
	2	−0.262	−0.235	<0.001*
	3	−0.242	−0.224	0.001*
MTG	1	−0.185	−0.165	0.010*
	2	−0.205	−0.180	0.004*
	3	−0.174	−0.154	0.018*
Superior frontal gyrus	1	−0.002	−0.002	0.976
	2	−0.004	−0.004	0.952
	3	0.046	0.043	0.618
Middle frontal gyrus	1	−0.065	−0.061	0.365
	2	−0.074	−0.068	0.311
	3	−0.044	−0.041	0.554
Total brain volume (grey + white matter)	1	−0.049	−0.013	0.497
	2	−0.066	−0.016	0.367
	3	0.117	0.101	0.112

Model 1 adjusted for age, years of education and sex, model 2 additionally adjusted for type 2 diabetes-related characteristics (duration of type 2 diabetes, HbA1c and glucose-lowering medication for type 2 diabetes) and model 3 additionally adjusted for other cardiovascular risk factors (total cholesterol, systolic and diastolic blood pressure, and smoking status)

^*p<0.05