Figure 5.

Coating morphology dictates contact pressures and delivery distributions. (A, B) Schematic representation of the microgeometry used to evaluate microscopic contract stresses exerted by disk shaped (C) and needle (D) coating particles. Dashes denote the mean macroscopic contact pressure predicted by the balloon angioplasty model. (E) Diamonds: mean PCT per unit length for the disk/flake (from Fig 4C) plotted against the corresponding microindentation pressure (from panel C) at the same distance from the proximal end. Solid line depicts best fit line with zero intercept and slope= 0.171 %/mm/kPa (R²=0.8690). (Ei) Computed PCT distribution based on panel C and the linear fit from panel E. (F) Diamonds: mean PCT per unit length for the needle coatings (from Fig 4 D, E) plotted against the corresponding microindentation pressure (from panel D) at the same distance from the proximal end. Solid line depicts segment linear fit (Eq. 3) with Slope 1= 0.083 %/mm/kPa, Slope 2= 0.009 %/mm/kPa and threshold pressure for slope change, p₀=6.3 kPa (R²=0.8614). (Fi) Computed PCT distribution based on panel D and the segment linear fit from panel F.