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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Respir Physiol Neurobiol. 2020 Aug 14;282:103525. doi: 10.1016/j.resp.2020.103525

FIGURE 2: Respiratory Deficits Persist Through 12 Months of Age in Optn−/− mice.

FIGURE 2:

Measures of respiratory function – frequency (A), tidal volume (B), minute ventilation (C), peak inspiratory flow (D), peak expiratory flow (E) – evaluated under normoxia (FiO2: 0.21, N2 balance) (“Baseline”) and a maximal respiratory challenge with hypoxia + hypercapnia (FiCO2: 0.7, FiO2: 0.10, N2 balance) (“Challenge”). At 12 mo of age, Optn−/− mice still do not display respiratory insufficiency at baseline, but after a respiratory challenge have a decrease in tidal volume, minute ventilation, peak inspiratory flow and peak expiratory flow compared to WT controls. Frequency is no longer significantly different during the respiratory challenge at 12 mo of age. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001