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The “Two-pronged complex” is constructed by combining the anti-atherogenic platform of mDNP-LXR-L with SR-A siRNA. This novel “Two-pronged” approach is aimed to simultaneously deliver siRNA to knock down the expression of SR-A to reduce cholesterol influx and deliver LXR-L to increase the expression of cholesterol transporters ABCA1/ABCG1 to enhance cholesterol efflux, thus leading to atherosclerotic plaque regression.
