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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Biomaterials. 2020 Aug 15;260:120333. doi: 10.1016/j.biomaterials.2020.120333

Figure 5. Treatment with Two-pronged complex reduces cellular cholesterol accumulation.

Figure 5.

MPMs were either left untreated (No/T) or treated with mDNP complexed with SR-A siRNA (0.25 μg/ml) or mDNP-LXR-L (5 μg/ml) or Two-pronged complex (20:1 w/w). After 24 h, lipid accumulation was induced by incubation with AcLDL (25 μg/ml) for additional 24 h. One set of cells were fixed, stained with Oil Red O and imaged (A). Total lipids were extracted from the parallel set and total cholesterol levels were determined and normalized to total cellular protein (B). Data are shown as Mean ± SD, n=3, *P<0.05 and NS-not significant.