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. 2020 Sep 18;11:553962. doi: 10.3389/fmicb.2020.553962

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Copyright © 2020 Shapira, Rankine-Wilson, Chao, Pichler, Rens, Pfeifer and Av-Gay.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Confirmation of DDUG inhibition of M.tb growth in infected THP-1 cells. Dose-dependent inhibition of M.tb:THP-1 intracellular growth by novel and established compounds, normalized to 1% DMSO negative control (0% inhibition) (A). CI, confidence interval. DDUG inhibition of M.tb growth in infected bone marrow derived macrophages (BMDM) cells (B). Dose-dependant cell loss of THP-1 (red) and bone marrow derived macrophages (BMDM) cells (green) (C). M.tb intracellular growth inhibition by RNAi suppression of the DDUG target, CHK2, interpolated to the negative control (1% DMSO) set at 0% inhibition and the positive control (4 μM bedaquiline) defined as 100% inhibition (D). Each data point is an average of 4 independent trials, and error bars are the SEM.