Fig. 2.

Cytocompatibility of Blank-NPs and uptake of Coumarin-6 NPs by cells. Cytocompatibility testing and cell uptake of Blank-NPs were detected. Within 24 h–72 h, Blank-NPs had almost no inhibitory effect on the growth of EC and SMC in normoxia (A, a) and hypoxia (B, a), and the cell survival rate was basically above 75%. Coumarin-6 NPs can be successfully swallowed into cells by EC and SMC under normoxia (A, b) and hypoxia (B, b), and lysosomal escape has been achieved. (A,b & B,b)The white bars represent 20 μm, blue stands for DAPI and green represents coumarin 6. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)