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Illustration of strategy for construction and functionalization of the traceable CSeM/let-7b NPs (Li et al., 2018) (Copyright 2018, reproduced with permission from American Chemical Society). (A) Preparation of the traceable CSeM/let-7b NPs. Polyprodrug amphiphiles were self-assembled to load SPIONs and absorb let-7b antisense oligonucleotide. (B) Schematic illustration of the mechanism of the traceable CSeM/let-7b NPs controlling exogenous NSCs as BDNF source for AD therapy.
