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. 2020 Sep 18;8:838. doi: 10.3389/fchem.2020.00838

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Copyright © 2020 Liu, Li, Chen, Lin, Lai, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The preparation of Congo red and Rutin–loaded magnetic nanoparticles (Congo red/Rutin-MNPs): (1) DSPE-PEG-Congo red and DSPE-PEG-phenylboronic acid were used to improve the biocompatibility of magnetic nanoparticles through a micelle formation procedure. (2) Rutin was grafted onto the surface of the nanoparticles through the formation of a boronate ester bond between vicinal diols and phenylboronic acid. (B) Schematic interpretation of Congo red/Rutin-MNPs in vivo: (1) Congo red/Rutin-MNPs coinjected with mannitol penetrated the BBB. (2) Congo red/Rutin-MNPs detected amyloid plaques specifically, realized targeted delivery, and controlled release of Rutin by H₂O₂ (Hu et al., 2015) (Copyright 2015, reproduced with permission from John Wiley and Sons).