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. 2020 Sep 18;8:838. doi: 10.3389/fchem.2020.00838

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Copyright © 2020 Liu, Li, Chen, Lin, Lai, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic illustration of B-PDEA–mediated BDNF transfection of NSCs for ischemic stroke treatment (Jiang et al., 2019) (Copyright 2019, reproduced with permission from John Wiley and Sons). (i) B-PDEA complexes BDNF plasmids to form polyplexes used for transfection of NSCs. (ii) The transfected NSCs i.v. transplanted to MCAO mice migrate to the injured area in the brain, whose high level of ROS efficiently triggers B-PDEA's conversion to negatively charged polyacrylate and the release of BDNF plasmids for NSCs to express and excrete BDNF. The released BDNF stimulates nerve regeneration and functional reconstruction, giving rise to a significant therapeutic effect in ischemic stroke.