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. 2020 Sep 18;8:838. doi: 10.3389/fchem.2020.00838

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Copyright © 2020 Liu, Li, Chen, Lin, Lai, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Biotin-conjugated bilirubin nanoparticles (bt-BRNPs) are formed from biotin-PEG-bilirubin (bt-PEG-BR) and PEG-bilirubin (PEG-BR) (Lee et al., 2018) (Copyright 2018, reproduced with permission from Elsevier). (A,B) Scheme for the synthesis of bt-PEG-BR starting from free bilirubin and biotin-PEG (A) and the formation of bt-BRNPs by self-assembly from PEG-BRs and bt-PEG-BR in PBS (B). (C) Transmission electron microscopy (TEM) images of bt-BRNPs. Scale bar: 500 nm.