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. 2020 Sep 18;11:573475. doi: 10.3389/fphar.2020.573475

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Copyright © 2020 Yang, Hu, Xie, Chen, Fang, Zhu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of TLR4/NF-κB pathway on intestinal barrier function, cell migration and NLRP3 inflammasome in IEC-6 cells. (A) The protein expression of TLR4 was determined by western blot analysis. (B) The value of TEER. (C) Images of cellular wounds generated were photographed at 0 and 24 h (scale bar: 0.3 mm). Wound healing of IEC-6 cells was assessed by comparing the wound area at 24 h after treatment with that prior to treatment. (D) The expressions of NLRP3, pro-caspase-1, caspase-1, pro-IL-1β, IL-1β, and IL-18 at protein levels were determined by western blot analysis. The data represent the averages ± S.D. Significant differences between the treatment and control groups are indicated as *P < 0.05, **P < 0.01, ***P < 0.001. Significance was determined by one-way ANOVA.