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. 2020 Sep 18;11:01187. doi: 10.3389/fphar.2020.01187

Figure 2.

Figure 2

Knockout of GLT25D2 protected against APAP-induced hepatotoxicity. The wild-type and GLT25D2–/– mice were administered with APAP (500 mg/kg, i.p.) or saline for 8 h (n = 16, 8 males and 8 females). (A) Serum AST and ALT levels from different groups. Compared with the APAP-induced wild-type mice group, ***P < 0.0001. (B) Representative livers and H&E staining (200×) of livers from different groups. (C) The survival rate of mice was measured in the GLT25D2+/+ mice and GLT25D2–/– mice groups (15 mice/group).