Skip to main content
. 2020 Oct 5;5:57. doi: 10.21037/tgh.2020.02.08

Table 1. miRNAs are involved in GC progression and peritoneal metastasis.

miRNAs (Ref.) Location Association with GC Targeted genes and pathways Application
miR-30a-5p (41); miR-659-3p; mR-3917 Primary tumor with GC peritoneal metastasis Poor prognosis Unknown Diagnosis
miR-148-a (42); miR-26a (43,44) Plasma and GC tissue Tumor suppression FGF9 Biomarker; rescue invasion
miR-29 family (45) GC tissue Repress proliferation and metastasis CCND2 and matrix metalloproteinase-2 Monitoring tumor progression; miRNA-based therapeutics
miR-29a3p (46) GC cell lines Suppress GC metastasis HAS3 Potential therapeutic effector
miR-198 (47) GC tissue Inhibit tumor growth and promote GC apoptosis FGFR1 Diagnostic and therapeutic potential
miR140 (48) GC tissue Suppress GC proliferation and growth PD-L1 Potential effector in immunotherapeutics
miR-383 (49) GC cells Inhibit GC proliferation Cyclin E2 Candidate to interrupt GC progression
miR-30d-5p (50) non-small cell lung cancer Inhibit motility Cyclin E Tumor suppressor
miR-30a-5p (51) GC tissue and cell lines Inhibit GC growth and metastasis IGF-1R Potential therapeutic effector
miR-338-3p (52) GC tissue and cell lines Restrain tumor growth and dissemination PTP1B Tumor suppressor
miR-93-5p (53) GC tissue Repress GC growth dissemination IFNAR Tumor suppressor
miR-421 (54); miR-129, miR21, etc. Gastric juice Gastric malignancy Unknown Biomarkers for screening GC
miR-181b-5p (55) GC ascites exosome Promote EMT, peritoneal metastases Unknown Combine with CEA as a potential biomarker in malignant ascites