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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Ticks Tick Borne Dis. 2020 Aug 2;11(6):101529. doi: 10.1016/j.ttbdis.2020.101529

Figure 3. Differential pathway activation in guinea pigs after repeat tick exposure.

Figure 3

A RNA-sequencing was performed at the bite site of guinea pigs 4 days after: the first tick exposure (n=3); 2nd tick exposures (n=2); third tick exposures (n=2), saliva immunized (n=3); and unbitten normal skin from a naïve mouse (n=3). Differentially expressed genes were defined as at least a 2-fold change and P value <0.05. These data are presented in a Venn diagram to indicate overlap between the different treatment groups. B Pathways analysis was performed using the differentially expressed genes. The top 15 significantly altered pathways are indicated (P value < 0.05). C A heat map of differentially activated pathways (−2 ≥ z-score ≥ 2) are represented.