Table 1.

GO terms (biological process) enriched in the perfused tubular liver tissue compared with the 2D‐cultured cells. GO terms were classified into four clusters by clustering analysis based on semantic similarity computation, and the top three of each cluster are shown

Cluster No.	GO ID	Description	Adjusted P‐value
1	GO:0007166	Cell surface receptor signaling pathway	1.63E‐16
	GO:0043062	Extracellular structure organization	8.05E‐14
	GO:0030198	Extracellular matrix organization	8.05E‐14
2	GO:0003008	System process	3.68E‐16
	GO:0009605	Response to external stimulus	3.40E‐16
	GO:0008015	Blood circulation	2.54E‐12
3	GO:0006811	Ion transport	4.55E‐14
	GO:0034220	Ion transmembrane transport	1.53E‐09
	GO:0055085	Transmembrane transport	5.05E‐09
4	GO:0045595	Regulation of cell differentiation	3.49E‐13
	GO:2000026	Regulation of multicellular organismal development	1.13E‐11
	GO:0001944	Vasculature development	6.01E‐09