Skip to main content
. 2020 Aug 18;29(16):2788–2802. doi: 10.1093/hmg/ddaa184

Figure 1.

Figure 1

Transcriptome-wide association analysis of Huntington disease clinical onset prioritizes novel candidate modifier genes. (A) Gene-level Z-scores of top modifier genes across tissues in the GeM-HD discovery cohort. Positive Z-scores indicate that increased gene expression is associated with a later age of clinical onset in patients, whereas negative Z-scores are associated with earlier onset. (B) Ternary plot of COLOC posterior probabilities colored by chromosomal location displaying TWAS regions that displayed evidence for colocalization (i.e. COLOC PP4 > 0.5) versus those regions that were either underpowered or where eQTL and GWAS signals represent independent associations. (C) Gene-level Z-scores from TWAS analyses in brain-related tissues for genes that showed evidence for colocalization in these regions in GTEx, as well as the CommonMind Consortium and ROSMAP (colored). These genes showed consistent associations in cortical tissues displaying that increased expression was associated with delayed HD onset.