Table 2. Adverse events.

Events	Overall (n=308)		Age <75 (n=249)		Age ≥75 (n=59)		P-value
	Any grade	≥ Grade 3	Any grade	≥ Grade 3	Any grade	≥ Grade 3	Any grade	≥ Grade 3
Any	74 (24.0%)	8 (2.6%)	55 (22.1%)	6 (2.4%)	19 (32.2%)	2 (3.4%)	0.127	0.652
Eczema/Pruritus	38 (12.3%)	2 (0.6%)	26 (10.4%)	1 (0.4%)	12 (20.3%)	1 (1.7%)	0.047	0.347
Malaise	11 (3.6%)		8 (3.2%)		3 (5.1%)		0.446
Headache/Myalgia	6 (1.9%)		5 (2.0%)		1 (1.7%)		1.000
Bilirubin increased	5 (1.6%)	2 (0.6%)	5 (2.0%)	2 (0.8%)
Constipation	3 (1.0%)		3 (1.2%)
Nausea	3 (1.0%)		1 (0.4%)		2 (3.4%)		0.095
Lung infection	2 (0.6%)	1 (0.3%)	2 (0.8%)	1 (0.4%)
ALT increased	2 (0.6%)	1 (0.3%)	1 (0.4%)	1 (0.4%)	1 (1.7%)		0.347
Dizziness	2 (0.6%)		2 (0.8%)
Heart failure	2 (0.6%)	2 (0.6%)	1 (0.4%)	1 (0.4%)	1 (1.7%)	1 (1.7%)	0.347	0.347
Cough	1 (0.3%)		1 (0.4%)
Others	4 (1.3%)		4 (1.6%)

ALT: alanine aminotransferase.