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. 2020 May 18;37(10):2875–2886. doi: 10.1093/molbev/msaa125

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 1. — Cancer gene duplications in mammalian genomes. (A) Phylogeny of 63 mammalian genomes used in this study, from Fritz et al. (2009). The tip label for humans (Homo sapiens) is in bold. (B) Copy numbers of tumor suppressor genes (TSGs) in each mammalian genome, normalized as the total number of TSG copies divided by the total number of TSG orthologs detected in a genome. (C) Normalized copy numbers for genes that are both tumor suppressor genes and oncogenes (TSGs/OGs) in each genome. (D) The normalized copy numbers of OGs. TSG and OG classifications were taken from the Cancer Gene Census (Sondka et al. 2018).'